profesionální vybavení genetických a cytogenetických pracovišť
SONDY  / MetaSystems / human / XL hematology

Katalogové číslo: D-5152-100-OG
Značení: Zelená Oranžová
Velikost balení: 100 µl
XL CSF1R BA consists of an orange-labeled probe hybridizing proximal to the CSF1R gene region at 5q32 extending into the gene up to intron 5 and a green-labeled probe hybridizing distal to the CSF1R gene region at 5q32-33.1 extending into the gene up to intron 5 (GRCh37/hg19).

In the 2016 World Health Organization classification of myeloid neoplasms and acute leukemia, the B-lymphoblastic leukemia/lymphoma subtype \'BCR-ABL1-like acute lymphoblastic leukemia\' (BCR-ABL1-like ALL), also called \'Philadelphia chromosome (Ph)-like ALL\', was recognized as a provisional entity. BCR-ABL1-like ALL is a high-risk subset of B-cell precursor ALL disorders characterized by a highly similar gene expression profile compared to Ph+ ALL in the absence of BCR-ABL1 fusions. Altered genes involved in the development and maintenance of Ph-like ALL are ABL1, ABL2, BLNK, CRLF2, CSF1R, DGKH, EPOR, FGFR1, IL-2RB, JAK2, LYN, NTRK3, PDGFRA, PDGFRB, PTK2B and TYK2.
CSF1R (colony stimulating factor 1 receptor) is a membrane-integrated tyrosine kinase receptor expressed by monocytes, macrophages, and other cells of the myeloid lineage. Binding of its ligands interleukin 34 or colony stimulating factor 1, respectively, leads to receptor homodimerization and auto-phosphorylation of the intracellular tyrosine kinase domains, subsequent signaling, and gene transcription. CSF1R-mediated signaling plays an important role in the differentiation and survival of monocytes and macrophages. In addition, CSF1R is a key factor in the tumorpermissive and immunosuppressive behavior of \'tumor associated macrophages\' by promoting tumor progression and survival via suppressing effector T-cell functions. Known translocation partner genes involved in CSF1R rearrangements, identified in Ph-like cases, are SSBP2, MEF2D and TBL1XR1. The most intensively characterized CSF1R fusion is SSBP2-CSF1R resulting from the translocation t(5;5)(q14;q32). The ABL1 inhibitors Imatinib and Dasatinib are known to have anti-survival and proapoptotic capacities on cells expressing the SSBP2-CSF1R fusion.

Cena za kus: pro registrované