XL Del(7)(q22q31)
The XL del(7)(q22q31) locus-specific probe detects deletions in the long arm of chromosome 7. The orange labeled probe hybridizes to a specific region at 7q22 including the KMT2E (formerly MLL5) gene. The green labeled probe hybridizes specifically to 7q31 and includes the MET proto-oncogene. A blue (aqua) labeled probe which hybridizes to the centromere of chromosome 7 functions as a reference probe.
The myelodysplastic syndromes and myeloproliferative disorders are associated with deregulated production of myeloid cells. According to WHO classification (2008) cytogenetic aberrations are observed in about 50 % of MDS cases. The most common aberrations are 5q-, 7/7q-, trisomy 8, del(20q), and inv(3) or t(3;3).
Partial or complete deletion of chromosome 7 is a common finding in MDS and AML. At least three distinct regions of common deletions have been identified: the band 7q22 and the more telomeric regions 7q31-32 and 7q36. In most studies monosomy 7/del 7q indicates as an isolated abnormality a significantly worse prognosis.
Cena za kus: pro registrované
The myelodysplastic syndromes and myeloproliferative disorders are associated with deregulated production of myeloid cells. According to WHO classification (2008) cytogenetic aberrations are observed in about 50 % of MDS cases. The most common aberrations are 5q-, 7/7q-, trisomy 8, del(20q), and inv(3) or t(3;3).
Partial or complete deletion of chromosome 7 is a common finding in MDS and AML. At least three distinct regions of common deletions have been identified: the band 7q22 and the more telomeric regions 7q31-32 and 7q36. In most studies monosomy 7/del 7q indicates as an isolated abnormality a significantly worse prognosis.
Cena za kus: pro registrované
