profesionální vybavení genetických a cytogenetických pracovišť
SONDY  / MetaSystems / human / XL hematology
XL Del(20q) plus

Katalogové číslo: D-5119-100-OG
Značení: Zelená Oranžová
Velikost balení: 100 µl
The XL Del(20q) plus probe detects deletions which occur in the long arm of chromosome 20. The probe mixture includes two probes: an orange labeled one which hybridizes to 20q12 and includes the proximal part of PTPRT, and a green labeled probe which hybridizes to 20q13 and includes the MYBL2 locus.

The myelodysplastic syndromes (MDS) are a group of hematopoietic stem cell disorders associated with ineffective hematopoiesis and peripheral blood cytopenias. MDS patients have a significant risk of progression to acute myeloid leukemia. In about 50% of de novo MDS cytogentic aberrations are observed, deletions are predominate, translocations are rare. Recurrent abnormalities are del(5q), monsomy 7, del(7q), del(20q), del(17p) and del(11q).

Del(20q) is a recurrent but rare aberration and is present in about 3-7% of MDS patients. The majority of cases have an interstitial deletion that is flanked by the PTPRT gene and includes the MYBL2 gene. Sole del(20q) is associated with a more favorable outcome.

Cena za kus: pro registrované