profesionální vybavení genetických a cytogenetických pracovišť
SONDY  / MetaSystems / human / XL hematology
XL MYC amp

Katalogové číslo: D-6008-100-OG
Značení: Zelená Oranžová
Velikost balení: 100 µl
The XL MYC amp probe detects amplifications in the long arm of chromosome 8. The orange labeled probe is designed to hybridize to the MYC locus at 8q24. A green labeled probe hybridizes to the 8cen region and functions as a control probe.

This probe is intended for methanol/acetic-acid fixed cells and tissue sections.

Amplification of MYC has been described in many types of tumor, including breast, cervical and colon cancers, as well as in squamous cell carcinomas of the head and neck, myeloma, non-Hodgkin\'s lymphoma, gastric adenocarcinomas and ovarian cancer. MYC is the most frequently amplified oncogene and the elevated expression of its gene product correlates with tumor aggression and poor clinical outcome.

The proto-oncogene MYC, located at 8q24.1, encodes a nuclear phosphoprotein transcription factor that has an integral role in a variety of cellular processes, such as cell cycle progression, proliferation, metabolism, adhesion, differentiation, and apoptosis.

Cena za kus: pro registrované